The UCL fixtures will kick off with two early matches at 18:45 GMT, where Club Brugge will take on Aston Villa, while Shakhtar Donetsk will face Young Boys.
The main lineup of fixtures will begin at 21:00 GMT, with Bayern Munich hosting Benfica in what promises to be a high-stakes clash.
Feyenoord will go head-to-head with RB Salzburg, while FK Crvena Zvezda will square off against Barcelona.
In Milan, Inter will meet Arsenal in a highly anticipated encounter, while Paris Saint-Germain will welcome Atletico Madrid to the Parc des Princes in a game expected to be fiercely contested.
Elsewhere, Sparta Prague will play Brest, and VfB Stuttgart will face Atalanta.
Full list, UCL fixtures:
Club Brugge vs Aston Villa – 18:45
Shakhtar Donetsk vs Young Boys – 18:45
Bayern Munich vs Benfica – 21:00
Feyenoord vs RB Salzburg – 21:00
FK Crvena Zvezda vs Barcelona – 21:00
Inter vs Arsenal – 21:00
Paris Saint-Germain vs Atletico Madrid – 21:00
Sparta Prague vs Brest – 21:00
VfB Stuttgart vs Atalanta – 21:00
